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Statistical analysis Data are expressed as mean standard error of the mean (SEM), unless stated otherwise

While these studies do not directly target the knee joint, they substantiate the core principles required for intra-articular therapy: 1) precise delivery of energy to a defined deep target, 2) the ability to trigger relevant biological responses (anti-inflammatory or neuromodulatory), and 3) a viable clinical safety profile

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| doi:10.1038/s41598-019-45906-5 Ghonimy A, Zhang DM, Farouk MH, Wang Q.: The Impact of Carnitine on Dietary Fiber and Gut Bacteria Metabolism and Their Mutual Interaction in Monogastrics

This pro-angiogenic activity, mediated at least in part through upregulation of VEGF receptor expression, is considered a key contributor to the accelerated tissue repair seen across different injury models